Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation
نویسندگان
چکیده
منابع مشابه
Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation
Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed "nanozyme." The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly(ethyleneglycol...
متن کاملSuperoxide dismutase isoenzymes in the human eye.
PURPOSE The authors determined the levels of the secreted, interstitially located extracellular superoxide dismutase (EC-SOD), the cytosolic copper- and zinc-containing SOD (CuZn-SOD), and the mitochondrial manganese-containing SOD (Mn-SOD) in tears, cornea, sclera, aqueous humor, lens, vitreous body, and retina of the human eye. METHODS SOD enzymatic activity was determined by the direct spe...
متن کاملSuperoxide Dismutase 1 and Cataract
"Pro captu lectoris habent sua fata libelli" (" According to the capabilities of the reader, books have their destiny ") Terentianus Maurus, 2 nd century roman grammarian
متن کاملThe Role of Manganese Superoxide Dismutase in Inflammation Defense
Antioxidant enzymes maintain cellular redox homeostasis. Manganese superoxide dismutase (MnSOD), an enzyme located in mitochondria, is the key enzyme that protects the energy-generating mitochondria from oxidative damage. Levels of MnSOD are reduced in many diseases, including cancer, neurodegenerative diseases, and psoriasis. Overexpression of MnSOD in tumor cells can significantly attenuate t...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2016
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2016/5194239